Lysostaphin and clarithromycin: a promising combination for the eradication of Staphylococcus aureus biofilms
نویسندگان
چکیده
منابع مشابه
Lysostaphin disrupts Staphylococcus aureus and Staphylococcus epidermidis biofilms on artificial surfaces.
Staphylococci often form biofilms, sessile communities of microcolonies encased in an extracellular matrix that adhere to biomedical implants or damaged tissue. Infections associated with biofilms are difficult to treat, and it is estimated that sessile bacteria in biofilms are 1,000 to 1,500 times more resistant to antibiotics than their planktonic counterparts. This antibiotic resistance of b...
متن کاملLysostaphin-induced, osmotically fragile Staphylococcus aureus cells.
Staphylococcus aureus FDA 209P cells when suspended in 24% (w/v) NaCl were rendered osmotically fragile by exposure to lysostaphin for time intervals ranging from 2 to 60 min. Such cells were analyzed chemically and serologically for evidence of residual cell wall material, were plated in hypertonic sucrose medium to determine revertibility to normal, and were subjected to manometric studies to...
متن کاملLysostaphin eradicates established Staphylococcus aureus biofilms in jugular vein catheterized mice.
OBJECTIVES Staphylococcus aureus infections associated with indwelling devices can be very difficult to treat due to the recalcitrant nature of bacterial biofilms to conventional antibiotics. Lysostaphin has been shown to clear S. aureus biofilms in vitro, and in this study we determined whether lysostaphin could also eradicate established S. aureus biofilms on implanted jugular vein catheters ...
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Background and Objectives: Biosurfactants are amphiphilic molecules produced by microorganisms that due to surfactant activity, have several applications in different industries such as cleaning, emulsification, foaming and dispersion. The aim of this study was to investigate the effect of biosurfactant extracted from saccharomycess cerevisiae on biofilm formation of staphylococcus aureus (PTC...
متن کاملCoral-Associated Bacteria as a Promising Antibiofilm Agent against Methicillin-Resistant and -Susceptible Staphylococcus aureus Biofilms
The current study deals with the evaluation of two coral-associated bacterial (CAB) extracts to inhibit the biofilm synthesis in vitro as well as the virulence production like hemolysin and exopolysaccharide (EPS), and also to assess their ability to modify the adhesion properties, that is cell surface hydrophobicity (CSH) of methicillin-resistant (MRSA) and -susceptible Staphylococcus aureus (...
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ژورنال
عنوان ژورنال: International Journal of Antimicrobial Agents
سال: 2011
ISSN: 0924-8579
DOI: 10.1016/j.ijantimicag.2011.02.009